9/20/2023 0 Comments Chimera tool rm 917The catalytic amine oxidase domain (AOD) houses a single, non-covalently bound flavin adenine dinucleotide (FAD) cofactor required for catalysis while the N-terminal SWI3p, Rsc8p, and Moira (SWIRM) domain is commonly found in chromatin-associating proteins ( Fig. This 852 amino acid (aa) polypeptide is composed of three structured domains ( Fig. KDM1A is a flavin-dependent amine oxidase that demethylates mono- and dimethylated lysine residues at positions 4 and 9 on histone H3 (H3K4me1/2 and H3K9me1/2), leading to gene activation and repression, respectively. In 2004, lysine-specific demethylase 1A (KDM1A also known as LSD1/BHC110/AOF2/KIAA0601/p110b) became the first histone demethylase to be isolated and characterized and has subsequently been identified as a potential therapeutic target.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |